中文名 | TYRPHOSTIN B46 |
英文名 | TYRPHOSTIN B46 |
别名 | 化合物AG 555 (E)-2-氰基-3-(3,4-二羟基苯基)-N-(3-苯基丙基)丙烯酰胺 |
英文别名 | AG 555 TYRPHOSTIN B46 TYRPHOSTIN AG 555 N-(3-PHENYLPROPYL)-3,4-DIHYDROXY-ALPHA CYANOCINNAMIDE ALPHA-CYANO-(3,4-DIHYDROXY)-N-(3-PHENYLPROPYL)CINNAMIDE N-(3'-PHENYLPROPYL)-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(3-PHENYLPROPYL)-2-PROPENAMIDE Tyrphostin B46, N-(3μ-Phenylpropyl)-3,4-dihydroxybenzylidenecyanoacetamide |
CAS | 133550-34-2 |
化学式 | C19H18N2O3 |
分子量 | 322.36 |
密度 | 1.273±0.06 g/cm3(Predicted) |
沸点 | 621.1±55.0 °C(Predicted) |
溶解度 | DMSO或乙醇: 可溶性 |
酸度系数 | 8.82±0.10(Predicted) |
存储条件 | Inert atmosphere,Store in freezer, under -20°C |
体外研究 | AG 555 (100 μM) inhibits both the early stages (integration process) and the late stages (viral protein synthesis) in the virus life cycle. Tyrphostins AG555, which blocks Cdk2 activation, induces growth arrest of immortalized cells at G1-S and early S and is very effective in arresting the growth of EGFR overexpressor cells. Tyrphostin AG 555 can selectively suppress BPV-1 transcription through MAP kinase pathway activation and binding of phosphorylated Jun/ATF-2 at a novel intragenic regulatory sequence. Cell Proliferation Assay Cell Line: NIH/3T3 uninfected cells and NIH/3T3-Mo-MuLV chronically infected cells. Concentration: 100 μM. Incubation Time: 1 hour. Result: Inhibited Mo-MuLV proviral DNA integration. |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.102 ml | 15.511 ml | 31.021 ml |
5 mM | 0.62 ml | 3.102 ml | 6.204 ml |
10 mM | 0.31 ml | 1.551 ml | 3.102 ml |
5 mM | 0.062 ml | 0.31 ml | 0.62 ml |
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